GLPG0187

Inoa Kimia:

(S)-3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino)-2-((4-methoxyphenyl)sulfonamido)ʻakika propanoic

SMILES Code:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

Code InChi:

InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1

Ki InChi:

CXHCNOMGODVIKB-VWLOTQADSA-N

Hua'ōlelo:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

Ma kahi hōʻike paʻa-phase, hōʻike ʻo GLPG0187 i ke koho no kekahi mau mea hoʻokipa RGD integrin me IC50s o 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM no αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, a me αvβ8. ʻO GLPG0187 kahi mea hoʻopaneʻe ikaika o ka osteoclastic bone resorption a me ka angiogenesis. Hoʻonui ʻia ka lāʻau E-cadherin/vimentin i ka lāʻau lapaʻau me GLPG0187, e hoʻolilo i nā cell i kahi epithelial, sessile phenotype. ʻO GLPG0187 ka nui o ka nui o ka aldehyde dehydrogenase subpopulation kiʻekiʻe o nā maʻi maʻi prostate [1]. ʻO GLPG0187 ka hopena o ka lāʻau lapaʻau i ka hoʻopuni ʻana a me ka puʻupuʻu. Hōʻike ʻo GLPG0187 i kahi hōʻemi nui i hilinaʻi ʻia i ka neʻe ʻana o ka cell tumor. ʻO ka GLPG0187 ma nā ʻāpana āpau e hōʻemi nui i ka hoʻonui ʻana o ka cell [2].

Pahuhopu: αvβ1