Vactosertib

Inoa Kimia:

N-((4-([1,2,4] triazolo [1,5-a] pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline

SMILES Code:

FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2

Code InChi:

InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12- 15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29 )

Ki InChi:

FJCDSQATIJKQKA-UHFFFAOYSA-N

Hua'ōlelo:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO Vactosertib, ka mea i ʻike ʻia ʻo EW-7197 he mea hoʻopale ALK5 ikaika. Ua hōʻike ʻo EW-7197 i ka hana anti-metastatic in vivo, e hōʻike ana i kona hiki ke hoʻohana ʻia ma ke ʻano he lāʻau anti-cancer. Kāohi ʻo EW-7197 i ka hōʻailona TGF-β/Smad. Hoʻopau ʻo EW-7197 i ka neʻe ʻana a me ka hoʻouka kaua ʻana o TGF-β1. EW-7197 kaohi i ka umauma ma'i 'a'ai metastasis i ka lung. EW-7197 e hooloihi i ke ola o ka BALB/c 4T1 mau iole ma o ke kaohi ana o EMT. EW-7197 inhibits metastasis a hoʻonui i ka hana o cytotoxic T lymphocytes (CTLs) ma 4T1 orthotopic grafted iole.

Kuhikuhi: ALK