ND-630

Inoa Kimia:

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide

SMILES Code:

O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O

Code InChi:

InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1

Ki InChi:

ZZWWXIBKLBMCSCS-FQEVSTJZSA-N

Hua'ōlelo:

ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

Kāohi ʻo ND-630 i ka hACC1 (IC50=2.1±0.2 nM) a me ka hACC2 (IC50=6.1±0.8 nM). Hiki ke hoʻohuli a kikoʻī loa no ka ACC. Kāohi ʻo ND-630 i ka hana ACC ma o ka launa pū ʻana i loko o ka phosphopeptide-acceptor a me ka pae dimerization o ka enzyme e pale i ka dimerization. ND-630 inhibits fatty acid synthesis me kahi EC50 o 66 nM i loko o nā pūnaewele HepG2 me ka hoʻololi ʻole i ka helu cell cell, ka hoʻopili ʻana i ka protein cellular, a me ka hoʻohui ʻana o ka acetate i ka cholesterol[1].

Pahuhopu: ACC