RGX-104 HCl

Inoa Kimia:

(R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride

SMILES Code:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

Code InChi:

InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

Ki InChi:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

Hua'ōlelo:

RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO RGX-104 he ate X receptor beta agonist me nā hana immunomodulating a me nā hana antineoplastic. Ma ka hoʻoponopono waha, koho a hoʻopaʻa ʻo RGX-104 iā LXRbeta, a laila e hoʻāla ai i ka hōʻailona LXRbeta-mediated, e alakaʻi ana i ka transcription o kekahi mau gene suppressor tumor a me ka hoʻohaʻahaʻa ʻana i kekahi mau genes promoter tumor. Hoʻoikaika maoli kēia i ka ʻōlelo o ka apolipoprotein E (ApoE), he protein suppressor tumor, i loko o nā pūnaewele a me kekahi mau mea pale. Hoʻoulu kēia i ka ʻōnaehana immune innate, ka hopena o ka hoʻopau ʻana o nā immunosuppressive myeloid-derived suppressor cell (MDSCs), nā pūnaewele a me nā cell endothelial i ka microenvironment tumor. Hoʻololi kēia i ka pale ʻana i ka pale ʻana, hoʻonui i nā pane anti-tumor immune a keʻakeʻa i ka hoʻonui ʻana o nā cell tumor.

Pahuhopu: LXRbeta