Bardoxolone methyl

Inoa Kimia:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4 ,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

SMILES Code:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Code InChi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H, 9-14,17H2,1-8H3/t20-,22?,24+,29+,30-,31-,32+/m1/s1

Ki InChi:

WPTTVJLTNAWYAO-OROHISIGSA-N

huaʻōlelo:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO ka synthetic oleanane triterpenoid CDDO (Item No. 81035) he mea hoʻoulu Nrf2 e kāohi ana i ka hoʻonuiʻana a hoʻoulu i ka hoʻokaʻawale a me ka apoptosis i loko o nā pūnaewele maʻi kanesa. Hoʻopaʻa ka C-28 methyl ester o CDDO (CDDO methyl ester) i ka cellular synthesis o inducible nitric oxide synthase (iNOS) a me ka inducible COX-2 i loko o nā macrophages kiʻi INF-γ-activated me ka waiwai IC50 o 0.11 nM. Hoʻoulu ia i ka apoptosis, hoʻoulu i ka ʻokoʻa, a kāohi i ka pane ʻana i ka maʻi maʻi i loko o nā cell tumor like ʻole ma o ke kāohi ʻana i ka hōʻailona IκBα kinase/NF-κB. Loaʻa i ka CDDO methyl ester ka hana antidiabetic ikaika, e hōʻemi ana i ka hōʻike cytokine proinflammatory i nā ʻiole diabetic type 2 momona momona a me nā ʻiole Leprdb/db a hoʻoulu i ka AMP-activated protein kinase a me ka LKB1 activation i ka ʻiʻo a me ka ate.

Kuhikuhi: NF-kB