Osimertinib Mesylate

Osimertinib Mesylate
  • inoa:AZD-9291 (Mesylate); Tagrisso; Osimertinib Mesylate
  • Helu helu:CPDB0137
  • Helu CAS.:1421373-66-1
  • Kaumaha Molekala:595.72
  • ʻO ke kumu hoʻohālike kimemika:C29H37N7O5S
  • No ka noiʻi ʻepekema wale nō, ʻaʻole no nā maʻi.

    Huahana Huahana

    Huahana Huahana

    Nui Puke Loaʻa Kumukuai (USD)
    500mg Loaʻa 100
    1g Loaʻa 180
    5g Loaʻa 600
    Nui hou aku E kiʻi i nā huaʻōlelo E kiʻi i nā huaʻōlelo

    Inoa Kimia:

    N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino )phenyl)acrylamide mesylate

    SMILES Code:

    CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

    Code InChi:

    InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28 )20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2 -6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

    Ki InChi:

    FUKSNUHSJBTCFJ-UHFFFAOYSA-N

    Hua'ōlelo:

    AZD-9291, AZD9291, AZD 9291, Tagrisso, Osimertinib Mesylate, 1421373-66-1

    Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

    Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

    wehewehe:

    ʻO Osimertinib, i kapa ʻia ʻo mereletinib a me AZD-9291, he kolu o ka hanauna EGFR inhibitor, i hōʻike i ka ʻōlelo hoʻohiki i nā haʻawina preclinical a hāʻawi i ka manaolana no nā poʻe maʻi me nā maʻi maʻi maʻi maʻi i kū i ke kūʻē i nā mea hoʻopaneʻe EGFR. Hoʻoikaika nui ʻo AZD9291 i nā hiʻohiʻona preclinical a ua ʻae maikaʻi ʻia i nā ʻano holoholona. Kāohi ia i ka hoʻololi ʻana a me ke kūpaʻa ʻana o ka EGFR i ka wā e mālama ai i ke ʻano maʻamau o EGFR i loaʻa i loko o nā ʻili maʻamau a me nā ʻōpū o ka ʻōpū, e hōʻemi ana i nā hopena ʻaoʻao i loaʻa i nā lāʻau lapaʻau i kēia manawa. Ua ʻae ʻia ʻo Osimertinib ma Nov. 2015.

    Pahuhopu: EGFR


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