GSK2256098

Inoa Kimia:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

SMILES Code:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Code InChi:

InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8- 6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

Ki InChi:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Hua'ōlelo:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO GSK2256098, ka mea i kapa ʻia ʻo GTPL7939, he mea hoʻopaneʻe focal adhesion kinase-1 (FAK) me nā hana antiangiogenic a antineoplastic. Kāohi ʻo FAK inhibitor GSK2256098 i ka FAK, hiki ke pale i ka hoʻoulu ʻana o ka integrin-mediated o nā ala transduction hōʻailona o lalo, me ERK, JNK/MAPK a me PI3K/Akt, no laila ke keʻakeʻa nei i ka neʻe ʻana o ka cell tumor, proliferation a me ke ola, a me ka angiogenesis tumor. Hoʻohana mau ʻia ka tyrosine kinase FAK ma o ka hoʻopaʻa ʻana i nā integrins i loko o ka extracellular matrix (ECM) akā hiki ke hoʻoponopono ʻia a hoʻāla ʻia i nā ʻano cell tumor.

Kuhikuhi: FAK