LX-2761

Inoa Kimia:

N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R, 5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide

SMILES Code:

O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1

Code InChi:

InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)3 4-32(2,3)31(40)33-16-17-35(4)5/h10-15,19,26-30,37-39H,7-9, 16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30-/m1/s1

Ki InChi:

BNPZTRDIESRGTC-IXYVTWBDSA-N

huaʻōlelo:

LX-2761, LX2761, LX 2761, 1610954-97-6

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO LX2761 kahi mea hoʻopaneʻe SGLT1 hana kūloko i ikaika loa i loko o ka vitro a hoʻopaneʻe i ka absorption glucose intestinal in vivo e hoʻomaikaʻi i ka mana glycemic. Loaʻa iā LX2761 ka hSGLt1 2.2 nM; hSGLT2 2.7 nM a me F% =<2. ʻO LX2761 kahi molekele ikaika loa, kūpaʻa kemika, a me ka liʻiliʻi liʻiliʻi i loaʻa i ka hōʻoia o ka manaʻo ma OGTT ma nā haʻahaʻa haʻahaʻa loa. Ua hoʻolālā ʻia ʻo LX2761 e noho i loko o ka ʻōpū ma hope o ka hoʻopuka waha ʻana i ka SGLT1 kūloko me ka ʻole o ka hoʻopili ʻana i ka mīkini SGLT1/2 i loko o ke kīpē.

Pahuhopu: SGLT1