ʻO Batefenterol

ʻO Batefenterol
  • inoa:Batefenterol; TD-5959; GSK961081
  • Helu helu:CPDD9951
  • Helu CAS.:743461-65-6
  • Kaumaha Molekala:740.254
  • ʻO ke kumu hoʻohālike kimemika:C40H42ClN5O7
  • No ka noiʻi ʻepekema wale nō, ʻaʻole no nā maʻi.

    Huahana Huahana

    Huahana Huahana

    Nui Puke Loaʻa Kumukuai (USD)
    50mg Loaʻa 200
    250mg Loaʻa 600
    500mg Loaʻa 900
    1g Loaʻa 1400
    Nui hou aku E kiʻi i nā huaʻōlelo E kiʻi i nā huaʻōlelo

    Inoa Kimia:

    "(R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)) methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"

    SMILES Code:

    O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

    Code InChi:

    InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)2 9-11-13-34(47)39-30(29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(1 6-19-46)53-40(51)44-32-10-6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22, 27, 35,42,47-48H,15-20,23-24H2,1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

    Ki InChi:

    URWYQGVSPQJGGB-DHUJRADRSA-N

    huaʻōlelo:

    Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

    Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

    Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

    wehewehe:

    ʻO Batefenterol he mea hoʻopiʻi muscarinic a me ka β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, a me 3.7 nM, no ka hM2, hM3, a me ka hβ2-AR, i loko o kahi hōʻike hoʻopaʻa radioligand). Hōʻike ʻo Batefenterol i ka hana agonist hβ2-AR ikaika (EC50 = 0.29 nM) me 440- a me 320-fold function selectivity ma luna o hβ1- a me hβ3-ARs. ʻiʻo a keʻakeʻa i ka pane bronchoconstrictor i kahi bronchoprotection puaʻa guinea hōʻike (ED50 = 6.4 µg/mL). Aia nā ʻano hana i loaʻa i ka batefenterol i nā hoʻokolohua lapaʻau e mālama i ka maʻi pulmonary obstructive chronic (COPD).

    Ka pahuhopu: β2-adrenoceptor


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