BAY-1895344

Inoa Kimia:

(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

SMILES Code:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

Code InChi:

InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25) ;1H/t13-;/m1./s1

Ki InChi:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Hua'ōlelo:

1876467-74-1；CAS:1876467-74-1；CAS:1876467-74-1；BAY-1895344, BAY1895344, BAY 1895344

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO BAY-1895344 kahi mea hoʻopaneʻe koho ATR (ataxia-telangiectasia a me Rad3 pili i ka protein) e pale ai i ka hoʻonui ʻana o kahi ākea ākea o nā laina cell tumor (median IC50 = 78 nM). Hoʻokumu ʻia ʻo BAY-1895344 no ka mālama ʻana i nā poʻe maʻi me nā maʻi maʻi paʻa paʻa a me nā lymphomas, a ke hele nei ia i kahi hoʻokolohua lapaʻau o ka pae I no ka palekana a me ka hoʻomanawanui no nā maʻi maʻi maʻi.

Pahuhopu: ATR