THZ531
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(R,E)-N-(4- (3-((5-chloro-4-- (1H-indol-3-yl))pyrimidin-2-yl)amino)piperidine-1-carbonyl) phenyl)-4- (dimethylamino) amma -2-enamide
Lambar SMILES:
"O=C(NC1=CC=C(C(N2C[C@H])(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1/C=C/CN(C)C"
Lambar InChi:
InChi=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22 (19-38) 35-30-33-18-25 (31)28 (36-) 30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5 ,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1
InChi Key:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Mabuɗin kalma:
THZ-531, THZ 531, THZ531, 1702809-17-3
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
THZ531 mai haɗakarwa CDK12 da CDK13 mai hanawa. Kinases masu dogaro da Cyclin 12 da 13 (CDK12 da CDK13) suna taka rawa mai mahimmanci a cikin tsarin kwafin kwayoyin halitta. THZ531 ba tare da jurewa ba yana kaiwa wani cysteine wanda ke wajen yankin kinase. THZ531 yana haifar da asarar bayyanar kwayar halitta tare da asarar elongating da hyperphosphorylated RNA polymerase II. THZ531 yana rage girman maganan ƙwayoyin amsawar DNA na lalata da mahimman abubuwan haɓaka-haɗe-haɗe-haɗe-haɗe. THZ531 ya haifar da mutuwar kwayar cutar apoptotic. Ƙananan kwayoyin da ke da ikon yin niyya na musamman CDK12 da CDK13 na iya taimakawa wajen gano nau'in ciwon daji waɗanda suka dogara musamman akan ayyukan kinase.
manufa: CDK
