| CAT # | Sunan samfur | Bayani |
| Saukewa: CPD9470 | Obeticolic acid | Obeticholic Acid (INT747; 6-ECDCA) wani labari ne na cholic acid wanda ke aiki azaman mai ƙarfi da zaɓi na FXR agonist yana nuna ayyukan anticholeretic a cikin ƙirar bera na cholestasis. Yana hana kumburi santsi mai santsi na ƙwayar tsoka da ƙaura da kuma haɓaka bambance-bambancen adipocyte kuma yana daidaita ayyukan adipose cell a cikin vivo. |
| Saukewa: CPD100579 | fexaramine | Fexaramine agonist ne na farnesoid X receptor (FXR), wanda shine mai karɓar nukiliya mai kunna bile acid wanda ke sarrafa kira na bile-acid, haɗuwa da sufuri, da kuma metabolism na lipid ta hanyar ayyuka a cikin hanta da hanji. Fexaramine yana da 100-ninka mafi girman kusanci ga FXR fiye da mahallin halitta kuma ya bayyana maƙasudin kwayoyin halitta da kuma wurin ɗaure akan FXR. Lokacin da aka ba da baki ga mice, fexaramine ya haifar da zaɓin ayyuka ta hanyar masu karɓar FXR a cikin hanji. |
| Saukewa: CPD100577 | Lithocholic acid | Levallorphan, wanda kuma aka sani da levallorphan tartate (USAN), wani mai gyara opioid ne na dangin morphinan da aka yi amfani da shi azaman analgesic na opioid da opioid antagonist/antidote. Yana aiki azaman antagonist na mai karɓar μ-opioid (MOR) kuma azaman agonist na κ-opioid receptor (KOR), kuma a sakamakon haka, yana toshe tasirin wakilai masu ƙarfi tare da babban aiki na ciki kamar morphine yayin da yake samar da analgesia lokaci guda. . A matsayin agonist na KOR, levallorphan na iya haifar da halayen tunani mai tsanani a isassun allurai ciki har da hallucinations, dissociation, da sauran tasirin psychotomimetic, dysphoria, tashin hankali, rudani, dizziness, ruɗewa, raguwa, ji na buguwa, da ban mamaki, sabon abu, ko mafarki mai ban tsoro. . (Madogararsa: https://en.wikipedia.org/wiki/Levallorphan). |
| Saukewa: CPD100575 | Turofexorate-Isopropyl | Turofexorate isopropyl, wanda kuma aka sani da WAY-362450 da XL335, yana da ƙarfi sosai, zaɓi, da agonist mai aiki na baki na farnesoid X receptor (FXR) (EC (50) = 4 nM, Eff = 149%), wanda ke rage kumburin hanta. da fibrosis a cikin samfurin murine na steatohepatitis maras barasa |
| Saukewa: CPD100574 | GW4064 | GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50为65 nM。 |
| Saukewa: CPD1549 | Tropifexor | Tropifexor labari ne kuma mai tsananin ƙarfi na FXR tare da EC50 na 0.2 nM. |
