THZ2
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
N-[3-[5-chloro-4- (1H-indol-3-yl) pyrimidin-2-yl]amino] phenyl] -3-[[(E) -4- (dimethylamino) amma-2- enoyl]amino]benzamide
Lambar SMILES:
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5
Lambar InChi:
InChi=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23 (17-22)37-31-34-19-26 (32)29 (38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H, 35,40)(H,36,41)(H,34,37,38)/b14-7+
InChi Key:
FONRCZUZCHXWBD-VGOFMYFVSA-N
Mabuɗin kalma:
THZ-2, THZ 2, THZ2, 1604810-84-5
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
THZ2, analog na THZ1, tare da yuwuwar magance cutar kansar nono sau uku (TNBC), yana da ƙarfi kuma mai zaɓi CDK7 inhibitor wanda ke shawo kan rashin zaman lafiyar THZ1 a cikin vivo. IC50: CDK7= 13.9 nM; Kwayoyin TNBC = 10 nM
manufa: CDK
