Riviciclib

Sunan Sinadari:

2- (2-chlorophenyl) -5,7-dihydroxy-8- ((2R,3S) -2- (hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-chromen-4-daya hydrochloride.

Lambar SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Lambar InChi:

InChi=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-) 21 (19) 20) 11-4-2-3-5-13 (11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

InChi Key:

OVTUOCTLAERQD-OJMBIDBESA-N

Mabuɗin kalma:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Solubility: 

Ajiya: 

Bayani:

Riviciclib, wanda kuma aka sani da P276-00, shine mai hana flavone da cyclin kinase (CDK) mai hanawa tare da yiwuwar aikin antineoplastic. P276-00 zaɓaɓɓen ɗaure da kuma hana Cdk4/cyclin D1, Cdk1/cyclin B da Cdk9/cyclin T1, serine/threonine kinases waɗanda ke taka muhimmiyar rawa a cikin ka'idar tsarin tantanin halitta da haɓakar salula. Hana waɗannan kinases yana haifar da kamawar ƙwayar ƙwayar cuta a lokacin canjin G1/S, wanda hakan zai haifar da ƙaddamar da apoptosis, da kuma hana yaduwar ƙwayar ƙwayar cuta.

manufa: CDK