| Saukewa: CPDB0157 | Saukewa: BI-847325 | BI-847325 shine mai hanawa MEK/Aurora kinase mai zaɓi mai zaɓi tare da ƙimar IC50 na 3, 25, 15, 25, da 4 nM don X. laevis Aurora B, ɗan adam Aurora A da Aurora C, da mutum MEK1 da MEK2, bi da bi. Zai iya hana haɓakawa da rayuwa na duka hanyoyin magani-naive da magungunan ƙwayoyin cuta na melanoma, yana rage ma'anar MEK da Mcl-1 yayin da yake haɓaka bayanin furotin pro-apoptotic Bim. A 70 mg / kg, BI-847325 yana haifar da apoptosis a cikin jiyya-naive da magani mai jurewa xenografted melanoma a cikin vivo. |
