Voruciclib

Sunan Sinadari:

2- (2-Chloro-4- (trifluoromethyl) phenyl) -5,7-dihydroxy-8- ((2R,3S) -2- (hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-1-benzopyran -4-daya

Lambar SMILES:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Lambar InChi:

InChi=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(32-21) 1 9)20)11-3-2-10 (6-13 (11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

InChi Key:

MPGRAKIAJJGMM-OCCSQVGLSA-N

Mabuɗin kalma:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Solubility: 

Ajiya: 

Bayani:

Voruciclib, wanda kuma aka sani da P1446A-05, shine mai hana furotin kinase na musamman don kinase 4 (CDK4) mai dogara da cyclin tare da yiwuwar aikin antineoplastic. CDK4 inhibitor P1446A-05 musamman yana hana CDK4-matsakaici G1-S lokaci mika mulki, kama hawan keke da kuma hana ciwon daji girma. Ana samun serine / threonine kinase CDK4 a cikin hadaddun tare da nau'in D-type G1 cyclins kuma shine kinase na farko don kunnawa akan haɓakar mitogenic, sakin sel daga matakin quiescent zuwa matakin hawan keke na G1 / S; CDK-cyclin complexes an nuna su phosphorylate da retinoblastoma (Rb) transcription factor a farkon G1, murkushe histone deacetylase (HDAC) da kuma toshe transcriptional danniya.

Saukewa: CDK4