| CAT # | Sunan samfur | Bayani |
| Saukewa: CPD100573 | Saukewa: PF-05175157 | PF-05175157 shine mai hanawa mai ƙarfi da zaɓi na duka acetyl-CoA carboxylase isoform ACC1 wanda ke da farko a cikin hanta da adipose nama da isoform ACC2 wanda ke mamaye kwarangwal da tsokar zuciya, tare da ƙimar IC50 na 27 nM da 33 nM, bi da bi. ACC inhibitors suna hana de novo lipogenesis kuma suna haɓaka β-oxidation na fatty acid mai tsayi tare da yuwuwar jiyya na nau'in ciwon sukari na 2, hanta steatosis, da kansa. |
| Saukewa: CPD100572 | ND-646 | ND-646 shine mai hana allosteric na ACC enzymes ACC1 da ACC2 wanda ke hana ACC subunit dimerization-don kashe kirar fatty acid a cikin vitro da in vivo. Maganin ND-646 na yau da kullun na xenograft da ƙirar ƙirar linzamin kwamfuta na NSCLC sun hana haɓakar ƙari. Lokacin gudanar da shi azaman wakili ɗaya ko a hade tare da ma'aunin kula da miyagun ƙwayoyi carboplatin, ND-646 da alama an hana ci gaban cutar huhu a cikin Kras; Trp53-/- (wanda aka fi sani da KRAS p53) da Kras; Stk11-/- ( kuma aka sani da KRAS Lkb1) ƙirar linzamin kwamfuta na NSCLC. ND-646 ya inganta inganci lokacin da aka haɗe shi da carboplatin, wani abu na yau da kullun na magungunan chemotherapeutic da ake amfani da su don kula da NSCLC na ɗan adam. |
| Saukewa: CPD100571 | Saukewa: CP-640186 | CP-640186 mai ƙarfi ne mai hanawa na ACCs masu shayarwa kuma yana iya rage nauyin jiki da haɓaka haɓakar insulin a cikin dabbobin gwaji. CP-640186 kwanan nan an nuna shi zama mai hanawa mai ƙarfi na isoforms na ACC masu shayarwa tare da ƙimar IC50 na kusan 55 nM. Wannan a halin yanzu shine kadai aka ruwaito mai hanawa ACCs masu shayarwa. A cikin al'adun tantanin halitta da kuma a cikin nau'ikan dabbobi, CP-640186 na iya rage matakan malonyl-CoA nama, hana fatty acid biosynthesis, kuma yana haɓaka iskar oxygen mai kitse. Mafi mahimmanci, CP-640186 na iya rage yawan kitsen jiki da nauyin jiki, da inganta haɓakar insulin, tabbatar da ACCs a matsayin maƙasudin magungunan rigakafin kiba da magungunan ciwon sukari. |
| Saukewa: CPD1592 | ND-630 | ND-630 shine mai hana acetyl-CoA carboxylase (ACC) mai hanawa; yana hana mutum ACC1 da ACC2 tare da ƙimar IC50 na 2.1 da 6.1 nM, bi da bi. |
