| CAT # | Sunan samfur | Bayani |
| Saukewa: CPD100464 | Erdafitinib | Erdafitinib, wanda kuma aka sani da JNJ-42756493, mai ƙarfi ne kuma zaɓaɓɓe na baka, mai hana mai karɓar haɓakar girma na pan fibroblast (FGFR) tare da yuwuwar aikin antineoplastic. Bayan gudanar da baki, JNJ-42756493 yana ɗaure zuwa kuma yana hana FGFR, wanda zai iya haifar da hanawar hanyoyin watsa siginar da ke da alaka da FGFR kuma ta haka ne hana yaduwar ƙwayar ƙwayar cuta da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta a cikin FGFR-overexpressing ƙwayoyin tumor. FGFR, wanda aka haɓaka a cikin nau'ikan ƙwayoyin ƙwayar cuta da yawa, shine mai karɓar tyrosine kinase mai mahimmanci don haɓaka ƙwayar ƙwayar cuta, rarrabuwa da rayuwa. |
| Saukewa: CPD3618 | TAS-120 | TAS-120 shine mai hanawa ta baki na mai karɓar haɓakar haɓakar fibroblast (FGFR) tare da yuwuwar aikin antineoplastic. FGFR inhibitor TAS-120 zaɓaɓɓe kuma ba tare da jujjuyawa ba yana ɗaure zuwa kuma yana hana FGFR, wanda zai iya haifar da hanawa duka hanyar watsa siginar siginar FGFR da haɓakar ƙwayar ƙwayar cuta, da haɓakar mutuwar ƙwayoyin cuta a cikin FGFR-overexpressing ƙwayoyin tumor. FGFR shine mai karɓar tyrosine kinase mai mahimmanci don haɓaka ƙwayar ƙwayar ƙwayar cuta, bambance-bambance da rayuwa kuma an daidaita maganarsa a yawancin nau'in ƙwayar ƙwayar cuta. |
| Saukewa: CPDB1093 | Derazantinib; ARQ-087 | Derazantinib, wanda kuma aka sani da ARQ-087, shine mai hanawa ta baki na mai karɓar haɓakar haɓakar fibroblast (FGFR) tare da yuwuwar aikin antineoplastic. |
| Saukewa: CPDB0942 | BLU-554 | BLU-554 shine mai hanawar fibroblast girma factor 4 (FGFR4) mai hanawa mai yuwuwa don maganin cututtukan hanta da cholangiocarcinoma. |
| Saukewa: CPD0999 | H3B-6527 | H3B-6527 (H3 Biomedicine) mai hanawa FGFR4 ne mai zaɓe mai ƙarfi tare da aiki mai ƙarfi na antitumor a cikin FGF19 haɓakar layukan salula da beraye. |
| Saukewa: CPD0997 | Saukewa: FGF401 | FGF-401 mai hanawa ne na FGFR4 da aka samo daga patent WO2015059668A1, misali misali 83; yana da IC50 na 1.9 nM. |
| Saukewa: CPDB0053 | Saukewa: AZD4547 | AZD 4547 shine mai zaɓin zaɓi na mai karɓa na fibroblast girma factor receptor (FGFR) tyrosine kinase tare da ƙimar IC50 na 0.2, 2.5, da 1.8 nM don FGFR1, 2, da 3, bi da bi. |
| Saukewa: CPD3610 | BLU-9931 | BLU9931 mai ƙarfi ne, zaɓi, kuma mai hanawa FGFR4 wanda ba zai iya jurewa ba tare da IC50 na 3 nM, game da 297-, 184-, da 50-ninka zaɓi akan FGFR1/2/3, bi da bi. |
