Saukewa: SEL120-34A

Sunan Sinadari:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij] quinoline Hydrochloride

Lambar SMILES:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Lambar InChi:

InChi=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

InChi Key:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Mabuɗin kalma:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Solubility: 

Ajiya: 

Bayani:

SEL120-34A shine mai hanawa CDK8 mai ƙarfi da zaɓi mai aiki a cikin sel AML tare da manyan matakan serine phosphorylation na STAT1 da STAT5 yankuna transactivation. EL120-34A yana hana phosphorylation na STAT1 S727 da STAT5 S726 a cikin ƙwayoyin ciwon daji a cikin vitro. A koyaushe, an lura da ƙa'idodin STATs- da NUP98-HOXA9- masu dogaro da rubutun a matsayin babban tsarin aiki a vivo.

Saukewa: CDK8