Saukewa: FLT3

CAT #	Sunan samfur	Bayani
Saukewa: CPDB0099	Quizartinib; AC-010220; AC-220	Quizartinib shine mai hanawa na tyrosine kinase 3 da ke da alaka da FMS (FLT3; Kd = 1.6 nM) kuma yana nuna babban zaɓi don FLT3 lokacin da aka gwada shi akan wani panel na 227 ƙarin kinases. Yana hana yaduwar kwayar cutar sankarar jini ta mutum MV4-11, wanda ke dauke da maye gurbin FLT3-ITD homozygous, tare da darajar IC50 na 0.56 nM.1 A 1 mg / kg / day, an nuna quizartinib don ƙaddamar da rayuwa a cikin linzamin kwamfuta. samfurin FLT3-ITD m myeloid cutar sankarar bargo da kuma kawar da ciwace-ciwace a cikin samfurin xenograft na linzamin kwamfuta na FLT3 a 10 mg/kg.