Alvocidib

Sunan Sinadari:

2- (2-chlorophenyl) -5,7-dihydroxy-8- ((3R,4S) -3-hydroxy-1-methylpiperidin-4-yl) -4H-chromen-4-daya

Lambar SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Lambar InChi:

InChi=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21 (19) 20) 11-4-2-3-5-13 (11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- ,17+/m1/s1

InChi Key:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Mabuɗin kalma:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Solubility: 

Ajiya: 

Bayani:

Alvocidib wani abu ne na roba N-methylpiperidinyl chlorophenyl flavone fili. A matsayin mai hana cyclin-dogara kinase, alvocidib yana haifar da kamawar kwayar halitta ta hanyar hana phosphorylation na cyclin-dependent kinases (CDKs) da kuma ta hanyar ƙaddamar da cyclin D1 da D3 magana, wanda ya haifar da kama G1 cell cycle da apoptosis. Wannan wakili kuma mai gasa ne mai hana aikin adenosine triphosphate. Bincika gwaje-gwajen asibiti masu aiki ko rufaffiyar gwajin asibiti ta amfani da wannan wakili.

manufa: CDK