BS-181

Sunan Sinadari:

N5-(6-aminohexyl) -N7-benzyl-3-isopropylpyrazolo [1,5-a] pyrimidine-5,7-diamine hydrochloride

Lambar SMILES:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Lambar InChi:

InChi=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(27-22) 19) 28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3, (H,24,27);1H

InChi Key:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Mabuɗin kalma:

Solubility: 

Ajiya: 

Bayani:

BS-181 babban zaɓi ne mai hana CDK don CDK7 tare da IC(50) na 21 nmol/L. Gwajin wasu CDKs da kuma wani 69 kinases ya nuna cewa BS-181 kawai ya hana CDK2 a matakan ƙasa da 1 micromol/L, tare da hana CDK2 35-ninka ƙasa da ƙarfi (IC(50) 880 nmol/L) fiye da CDK7. A cikin sel na MCF-7, BS-181 ya hana phosphorylation na CDK7 substrates, inganta tsarin sake zagayowar cell da apoptosis don hana ci gaban ƙwayoyin cutar kansa, kuma ya nuna tasirin antitumor a cikin vivo.

Saukewa: CDK7