Saukewa: LDC000067

Sunan Sinadari:

3-[6- (2-Methoxyphenyl)-4-pyrimidinyl]amino] benzenemethanesulfonamide

Lambar SMILES:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2=C1)(N)=O

Lambar InChi:

InChi=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Mabuɗin kalma:

LDC000067; LDC-000067; Farashin 000067

Solubility: 

Ajiya: 

Bayani:

LDC000067 mai ƙarfi ne kuma mai hanawa CDK9. LDC000067 an hana rubutun in vitro a cikin gasa-ATP da kuma dogaro da kashi. Bayyanar bayanan kwayoyin halitta na sel da aka bi da su tare da LDC000067 sun nuna raguwar zaɓi na mRNAs na ɗan gajeren lokaci, gami da mahimman masu kula da yaduwa da apoptosis. Binciken hadawar de novo RNA ya ba da shawarar faffadan ingantacciyar rawar CDK9. A matakin kwayoyin halitta da salon salula, LDC000067 ya haifar da tasirin halayen halayen hana CDK9 kamar ingantaccen dakatarwar RNA polymerase II akan kwayoyin halitta kuma, mafi mahimmanci, shigar da apoptosis a cikin ƙwayoyin kansa. LDC000067 yana hana P-TEFb-dogara a rubutun in vitro. Yana haifar da apoptosis a cikin vitro da in vivo a hade tare da BI 894999.

Saukewa: CDK9