Saukewa: CP-456773
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl) ((4- (2-hydroxypropan-2-yl)furan-2-yl) sulfonyl) amide
Lambar SMILES:
O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Lambar InChi:
InChi=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12 (15) 9-13-6-4-8-16 (13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1
InChi Key:
LFQQNXFKPNZRFT-UHFFFAOYSA-M
Mabuɗin kalma:
MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium gishiri, Cytokine saki inhibitory miyagun ƙwayoyi 3, 256-373-96
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
CP-456773, wanda kuma aka sani da MCC950 da CRID3, mai ƙarfi ne da zaɓi mai hanawa na cytokine da kuma NLRP3 inflammasome inhibitor don maganin cututtuka masu kumburi. CP-456773 yana hana interleukin 1β (IL-1β) ɓoyewa da aiki na caspase 1. MCC950 ya katange canonical da kunnawar NLRP3 na canonical a adadin nanomolar. MCC950 musamman ya hana kunna NLRP3 amma ba aIM2, NLRC4 ko NLRP1 inflammasomes ba. MCC950 ya rage samar da interleukin-1β (IL-1β) a cikin vivo kuma ya rage girman gwajin gwaji na autoimmune encephalomyelitis (EAE), samfurin cututtuka na sclerosis da yawa. MCC950 ne mai yuwuwar warkewa don cututtukan da ke da alaƙa da NLRP3, gami da cututtukan autoinflammatory da autoimmune, da kuma kayan aiki don ƙarin nazarin kumburin NLRP3 a cikin lafiyar ɗan adam da cuta.
Saukewa: NLRP3
