EAI-045

Ainm Ceimigeach:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

Còd SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Còd InChi:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11- 3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

iuchair InChi:

YTUFHOKUFOQRDF-UHFFAOYSA-N

Facal-luirg:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

EAI045 ia neach-bacadh EGFR cumhachdach agus roghnach. Bidh EAI045 ag amas air mutants EGFR taghte a tha an aghaidh dhrogaichean ach a’ sàbhaladh an gabhadair seòrsa fiadhaich. Tha EAI045 a’ cur bacadh air L858R/T790M-mutant EGFR le comas ìosal-nanomolar ann am measaidhean bith-cheimiceach.

Targaid: EGFR