GDC-0326

Ainm Ceimigeach:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

Còd SMILES:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Còd InChi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

iuchair InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Facal-luirg:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

Tha GDC-0326 na neach-dìon cumhachdach agus roghnach de α-Isoform de Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). Tha GDC-0326 a’ coileanadh ìre fìor àrd de roghainn thairis air cinnidhean eile. Tha CL plasma ìosal aig GDC-0326 ann an duine. Taobh a-staigh teaghlach PI3 kinase, tha ceithir isoforms PI3K clas I (α, β, δ, agus γ). De na isoforman sin, is e PI3Kα an fheadhainn as cumanta a tha co-cheangailte ri cansearan.

Targaid: PI3K