LDC000067

Igama Lekhemikhali:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

Ikhodi ye-SMILES:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Ikhodi ye-InChi:

I-InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

I-InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Igama elingukhiye:

LDC000067; I-LDC-000067; I-LDC 000067

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-LDC000067 iyi-CDK9 inhibitor enamandla futhi ekhethayo. I-LDC000067 ivinjwe ukulotshwa kwe-in vitro ngendlela yokuncintisana ne-ATP futhi encike kumthamo. Ukuchazwa kwephrofayili ye-Gene yamaseli aphathwe nge-LDC000067 kubonise ukuncishiswa okukhethiwe kwama-mRNA ahlala isikhathi esifushane, okuhlanganisa nabalawuli ababalulekile bokwanda kanye ne-apoptosis. Ukuhlaziywa kwe-de novo RNA synthesis kuphakamise indima enhle ehlukahlukene ye-CDK9. Ezingeni lamangqamuzana namaselula, i-LDC000067 iphinde yakhiqiza imiphumela yesici sokuvinjwa kwe-CDK9 njengokumisa isikhashana okuthuthukisiwe kwe-RNA polymerase II ezakhini zofuzo futhi, okubaluleke kakhulu, ukufakwa kwe-apoptosis kumaseli omdlavuza. I-LDC000067 ivimbela ukuloba kwe-in vitro okuncike ku-P-TEFb. Idala i-apoptosis ku-vitro kanye ne-vivo ihlanganiswe ne-BI 894999.

Ithagethi: CDK9