GSK2982772
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 500 |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2, I-4-triazole-3-carboxamide
Ikhodi ye-SMILES:
O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O
Ikhodi ye-InChi:
I-InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23- 24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14 -/m0/s1
I-InChi Key:
I-LYPAFUINURXJSG-AWEZNQCLSA-N
Igama elingukhiye:
GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
I-GSK2982772 iyi-receptor enamandla futhi ekhethayo Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate for the Treatment of Inflammatory Diseases. I-GSK2982772, okwamanje isesigabeni sesi-2a sezifundo zomtholampilo ze-psoriasis, i-rheumatoid arthritis, kanye ne-ulcerative colitis. I-GSK2982772 ibophezela ngamandla ku-RIP1 enemininingwane ecacile ye-kinase futhi inomsebenzi omuhle kakhulu ekuvimbeni izimpendulo eziningi zamaselula ezincike ku-TNF. I-RIP1 ivele njenge-kinase ebalulekile ekhuphukayo ekhonjiswe ukuthi ilawula ukuvuvukala ngokusebenzisa kokubili imisebenzi ethile ye-scaffolding kanye ne-kinase.
Ithagethi: RIP1
