I-BAZ2-ICR
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 500 |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile
Ikhodi ye-SMILES:
CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2
Ikhodi ye-InChi:
I-InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24) -26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3
I-InChi Key:
RRZVGDGTWNQAPW-UHFFFAOYSA-N
Igama elingukhiye:
BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
I-BAZ2-ICR iwuphenyo lwamakhemikhali oluhle kakhulu lwezifundo ezisebenzayo ze-BAZ2 bromodomains in vitro kanye ne-vivo. I-bromodomain equkethe amaprotheni i-BAZ2A/B idlala izindima ezibalulekile ekuhlelweni kabusha kwe-chromatin kanye nokulawulwa kwama-RNA angakhohlisi. I-BAZ2-ICR ine-IC50 (BAZ2A) = 130 nM; I-IC50(BAZ2B) = 180 nM; logD = 1.05; ukunyibilika okungu-25 mM (D2O) no-F = 70%.
Ithagethi: BAZ2