I-ABBV-744

Igama Lekhemikhali:

I-N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H -pyrrolo[2,3-c]pyridine-2-carboxamide

Ikhodi ye-SMILES:

O=C(C(N1)=CC(C(C2=CC(C)(O)C)=CC=C2OC3=C(C)C=C(F)C=C3C)=CN4C)=C1C4 =O)NCC

Ikhodi ye-InChi:

I-InChI=1S/C28H30FN3O4/c1-7-30-26(33)22-13-20-21(14-32(6)27(34)24(20)31-22)19-12-17(28( 4,5)35)8-9-23(19)36-25-15(2)10-18(29)11-16(25)3/h8-14,31,35H,7H2,1-6H3, (H,30,33)

I-InChi Key:

OEDSFMUSNZDJFD-UHFFFAOYSA-N

Igama elingukhiye:

ABBV-744, ABBV 744, ABBV744, 2138861-99-9

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-ABBV-744 iyi-BDII-ekhethiwe ye-BET bromodomain inhibitor esaphenywayo ukwelapha i-AML kanye nomdlavuza wendlala yesinye we-metastic castration-resistant.

Ithagethi: BET bromodomain