I-GDC-0077

Igama Lekhemikhali:

(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)amino)propanamide

Ikhodi ye-SMILES:

C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

Ikhodi ye-InChi:

I-InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21 ,26)/t9-,12-/m0/s1

I-InChi Key:

I-SGEUNORSOZVTOL-CABZTGNLSA-N

Igama elingukhiye:

GDC-0077, GDC0077, GDC 0077, 2060571-02-8

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-GDC-0077 iyi-PI3K inhibitor etholakala ngomlomo futhi ekhethiwe (IC50 = 0.038 + 0.003 nM) ene > ekhethwa ngokuphindwe ka-300 ngaphezu kwamanye ama-isoform e-Class I PI3K. I-GDC-0077 yenza umsebenzi wayo ngokubophezela kusayithi elibophezelayo le-ATP le-PI3K, ngaleyo ndlela ivimbele i-phosphorylation ye-PIP2 ku-PIP3.

Ithagethi: PI3K