I-RGX-104 HCl

Igama Lekhemikhali:

(R) -2-[3-[3-[2-Chloro-3-(trifluoromethyl))benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride

Ikhodi ye-SMILES:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

Ikhodi ye-InChi:

I-InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36 ,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27;/h2-17,20,24,30H,18- 19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

I-InChi Key:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

Igama elingukhiye:

I-RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-RGX-104 iyi-agonist ye-beta yokwamukela isibindi ye-X enemisebenzi engase ibe yi-immunomodulating kanye ne-antineoplastic. Lapho iphathwa ngomlomo, i-RGX-104 ikhomba ngokukhetha futhi ibophezela ku-LXRbeta, ngokwenza kanjalo ivule ukusayinda okuphakathi kwe-LXRbeta, okuholela ekulotshweni kofuzo oluthile lokucindezela isimila kanye nokwehliswa kofuzo oluthile lomgqugquzeli wesimila. Lokhu kuvula ikakhulukazi ukuvezwa kwe-apolipoprotein E (ApoE), iphrotheni ecindezela isimila, kumaseli wesimila kanye namaseli athile omzimba. Lokhu kwenza kusebenze isimiso somzimba sokuzivikela ezifweni, okuholela ekuncipheni kwamaseli e-immunosuppressive myeloid-derived suppressor cell (MDSCs), amaseli wesimila kanye namaseli e-endothelial ku-tumor microenvironment. Lokhu kunciphisa ukuvinjelwa kwamasosha omzimba, kuthuthukisa ukusabela kwamasosha omzimba e-anti-tumor futhi kuvimbele ukwanda kwamaseli wesimila.

Ithagethi: LXRbeta