EED226

Igama Lekhemikhali:

N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

Ikhodi ye-SMILES:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

Ikhodi ye-InChi:

I-InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-1 1-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

I-InChi Key:

DYIRSNMPIZZNBK-UHFFFAOYSA-N

Igama elingukhiye:

EED226, EED-226, EED 226, 2083627-02-3

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-EED226 iyisivimbeli esinamandla, esisebenza kahle futhi esikhethayo se-EZH2 kanye ne-EZH1 esihlolwe ngokumelene nohlu olubanzi lwezinhloso ze-epigenetic kanye ne-non-epigenetic. Yehlisa ngokunamandla umaki womhlaba wonke we-H3K27Me3 kumaseli futhi ibonise imiphumela ekhethiwe yokubulala amaseli kumaseli aphethe ukuguqulwa kwe-heterozygous Y641N. I-EED226 inokungeneka okumaphakathi njengoba kukalwa kumaseli e-Caco-2 kokuthi A→B=3.0x10-6 cm/s, ngesilinganiso se-efflux esingu-7.6[1].

Ithagethi: EED226