AZD-5069
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 500 |
| 500mg | O wa | 800 |
| 1g | O wa | 1200 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
N- (2- ((2,3-difluorobenzyl)thio) -6- ((2R,3S) -3,4-dihydroxybutan-2-yl) oxy) pyrimidin-4-yl)zetidine-1-sulfonamide
KỌỌDỌ SMILES:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Koodu InChi:
InChi=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13 (19)17 (12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1
Bọtini InChi:
QZECRCLSIGFCIO-RISCZKNCSA-N
Koko-ọrọ:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
AZD-5069 jẹ alagbara ati yiyan CXCR2 antagonist pẹlu agbara lati ṣe idiwọ ijira neutrophil sinu awọn ọna atẹgun ni awọn alaisan pẹlu COPD. A ṣe afihan AZD-5069 lati ṣe idiwọ isọmọ ti CXCL8 ti redio si CXCR2 eniyan pẹlu iye pIC50 ti 9.1. Pẹlupẹlu, AZD5069 ṣe idiwọ neutrophil chemotaxis, pẹlu pA2 ti isunmọ 9.6, ati ikosile moleku adhesion, pẹlu pA2 ti 6.9, ni idahun si CXCL1. AZD5069 jẹ alatako iparọ laiyara ti CXCR2 pẹlu awọn ipa ti akoko ati iwọn otutu ti o han lori ile elegbogi ati awọn kinetics abuda. AZD-5069 tun jẹ iwulo fun alaisan ni awọn ipo iredodo.
Àfojúsùn: CXCR2