GSK2982772

Orukọ Kemikali:

(S) -5-Benzyl-N- (5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo [b]-[1,4] oxazepin-3-yl) -4H-1,2, 4-triazole-3-carboxamide

KỌỌDỌ SMILES:

O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O

Koodu InChi:

InChi=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23- 24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14 -/m0/s1

Bọtini InChi:

LYPAFUINURXJSG-AWEZNQCLSA-N

Koko-ọrọ:

GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

GSK2982772 ti o lagbara ati ti o yan olugba Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate fun Itoju ti Awọn Arun Irun. GSK2982772 wa, lọwọlọwọ ni ipele 2a awọn iwadii ile-iwosan fun psoriasis, arthritis rheumatoid, ati ulcerative colitis. GSK2982772 ni agbara sopọ mọ RIP1 pẹlu iyasọtọ kinase pataki ati pe o ni iṣẹ ṣiṣe to dara julọ ni didi ọpọlọpọ awọn idahun cellular ti o gbẹkẹle TNF. RIP1 ti farahan bi kinase pataki ti o wa ni oke ti o ti han lati ṣe atunṣe iredodo nipasẹ mejeeji scaffolding ati kinase pato awọn iṣẹ.

afojusun: RIP1