GDC-0077
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 500 |
| 500mg | O wa | 800 |
| 1g | O wa | 1200 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
(S) -2- ((2- ((S)) -4- (difluoromethyl) -2-oxooxazolidin-3-yl) -5,6-dihydrobenzo [f] imidazo [1,2-d] [1,4] ]oxazepin-9-yl)amino)propanamide
KỌỌDỌ SMILES:
C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1
Koodu InChi:
InChi=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)2 5-12 (15 (19)20)8-29-18 (25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26 )/t9-,12-/m0/s1
Bọtini InChi:
SGEUNORSOZVTOL-CABZTGNLSA-N
Koko-ọrọ:
GDC-0077, GDC0077, GDC 0077, 2060571-02-8
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
GDC-0077 jẹ ẹnu ti o wa ni ẹnu ati yiyan PI3K inhibitor (IC50 = 0.038 + 0.003 nM) pẹlu> 300-agbo yiyan lori awọn isoforms Kilasi I PI3K miiran. GDC-0077 n ṣe iṣẹ ṣiṣe rẹ nipa sisọmọ si aaye isopọmọ ATP ti PI3K, nitorina ni idinamọ phosphorylation ti PIP2 si PIP3.
Àfojúsùn: PI3K
