EED226

Orukọ Kemikali:

N- (furan-2-ylmethyl) -8- (4- (methylsulfonyl) phenyl)-[1,2,4]triazolo [4,3-c] pyrimidin-5-amine

KỌỌDỌ SMILES:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

Koodu InChi:

InChi=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

Bọtini InChi:

DYIRSNMPIZZNBK-UHFFFAOYSA-N

Koko-ọrọ:

EED226, EED-226, EED 226, 2083627-02-3

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

EED226 jẹ agbara ti o ga julọ, ṣiṣe daradara ati oludanujẹ yiyan ti EZH2 ati EZH1 ti a ṣe iṣiro lodi si iwọn gbooro ti epigenetic ati awọn ibi-afẹde ti kii-epigenetic. O ni agbara dinku ami H3K27Me3 agbaye ninu awọn sẹẹli ati ṣe afihan yiyan awọn ipa pipa sẹẹli ninu awọn sẹẹli ti o ni iyipada heterozygous Y641N kan. EED226 ni ailagbara iwọntunwọnsi bi iwọn ninu awọn sẹẹli Caco-2 ni A→B=3.0x10-6 cm/s, pẹlu ipin efflux ni 7.6[1].

Ifojusi: EED226