AMG-510

Orukọ Kemikali:

4- ((S) -4-acryloyl-2-methylpiperazin-1-yl) -6-fluoro-7- (2-fluoro-6-hydroxyphenyl) -1- (2-isopropyl-4-methylpyridin-3-yl) )pyrido [2,3-d] pyrimidin-2 (1H) -ọkan

KỌỌDỌ SMILES:

O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4=O)CC1

Koodu InChi:

InChi=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22 (24)39)34 -29 (19) 38 (30 (41) 35-28) 27-17 (4) 10-11-33-25 (27) 16 (2) 3 / h6-11,14,16,18,39H,1 ,12-13,15H2,2-5H3/t18-/m0/s1

Bọtini InChi:

NXQKSXLFSAEQCZ-SFHVURJKSA-N

Koko-ọrọ:

AMG-510; AMG 510; AMG510

Solubility: 

Ibi ipamọ: 

Apejuwe:

AMG-510 jẹ apaniyan covalent KRAS G12C ti o lagbara. AMG-510 yan ni ibi-afẹde KRAS p.G12C mutant, ni boya DNA, RNA tabi ipele amuaradagba, ati idilọwọ, nipasẹ ọna ti a ko ti ṣalaye, ikosile ti ati/tabi ifihan sẹẹli tumo nipasẹ iyipada KRAS p.G12C. Eyi le ṣe idiwọ idagbasoke ni KRAS p.G12C-fifihan awọn sẹẹli tumo

afojusun: KRAS