BAY-293

Orukọ Kemikali:

(R) -6,7-dimethoxy-2-methyl-N- (1- (4- (2- ((methylamino)methyl) phenyl) thiophen-2-yl) ethyl) quinazolin-4-amine

KỌỌDỌ SMILES:

C[C@@H](NC1=C2C=C(OC)C(OC)=CC2=NC(C)=N1)C3=CC(C4=CC=CC=CC=C4CNC)=CS3

Koodu InChi:

InChi=1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11- 22( 30-4)23 (31-5)12-21 (20)28-16 (2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29 )/t15-/m1/s1

Bọtini InChi:

WEGLOYDTDILXDA-OAHLLOKOSA-N

Koko-ọrọ:

BAY-293, BAY 293, BAY293

Solubility: 

Ibi ipamọ: 

Apejuwe:

BAY-293 jẹ onidalẹkun SOS1 ti o lagbara ti o ṣe idiwọ imuṣiṣẹ RAS nipasẹ idalọwọduro ti ibaraenisepo RAS-SOS1. BAY-293) yiyan ṣe idiwọ ibaraenisepo KRAS-SOS1 pẹlu IC50 ti 21 nM ati pe o jẹ iwadii kemikali ti o niyelori fun awọn iwadii ọjọ iwaju.

Àkọlé: SOS1 inhibitor