Ozanimod

Orukọ Kemikali:

(S) -5- (3- (1- (2-hydroxyethyl) amino) -2,3-dihydro-1H-inden-4-yl) -1,2,4-oxadiazol-5-yl) -2 -isopropoxybenzonitrile

KỌỌDỌ SMILES:

N#CC1=CC(C2=NC(C3=CC=CC4=C3CC[C@@H]4NCCO)=NO2)=CC=C1OC(C)C

Koodu InChi:

InChi=1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3- 4-18-17 (19)7-8-20 (18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1- 2H3 / t20- / m0 / s1

Bọtini InChi:

XRVDGNKRPOAQTN-FQEVSTJZSA-N

Koko-ọrọ:

Ozanimod, RPC-1063, RPC1063, RPC 1063, 1306760-87-1

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

Ozanimod jẹ yiyan, modulator ti o wa ni ẹnu ti awọn olugba sphingosine-1-phosphate (S1P) S1P1 ati SIP5. O mu inu inu ti S1P1, dinku titan kaakiri B ati CCR7 (+) lymphocytes T, ati dinku ipalara ati awọn paramita arun ni awọn awoṣe arun autoimmune mẹta.1 Ozanimod wa ninu awọn idanwo ile-iwosan fun ifasẹyin ọpọ sclerosis ati ulcerative colitis.

Àfojúsùn: S1P