MSC2530818
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 400 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
Ikhowudi yoncumo:
O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
Ikhowudi ye-InChi:
InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1
Isitshixo se-InChi:
ODRITQGYYWHQGM-INIZCTEOSA-N
Igama elingundoqo:
MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-MSC2530818 yi-CDK8 Inhibitor enamandla, eKhethekileyo, kunye ne-Olly Bioavailable Bioavailable CDK8 IC50 = 2.6 nM; Ukuqikelelwa kwe-PK yomntu: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. I-MSC2530818 ibonisa ukhetho oluhle kakhulu lwe-kinase, i-biochemical kunye ne-cellular potency, ukuzinza kwe-microsomal, kwaye i-bioavailable ngomlomo. I-MSC2530818 ibonisa amandla afanelekileyo kunye nokukhetha ukuqhubela phambili kwi-preclinical in vivo efficacy kunye nezifundo zokhuseleko.
Ithagethi: CDK
