NTN21277

Igama leMchiza:

(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl))amino)-7-methoxyquinazolin-6-yl) oxy)pentyl)oxy)eth oxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Ikhowudi yoncumo:

O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N =CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C =C5

Ikhowudi ye-InChi:

InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43-/m1/s1

Isitshixo se-InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Igama elingundoqo:

I-Gefitinib esekelwe kwi-PROTAC 3; NTN21277; I-NTN-21277; NTN 21277

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-NTN21277, eyaziwa ngokuba yi-Gefitinib-based PROTAC 3 yi-VHL-recruiting PROTAC eyenza ukuthotywa kwe-EGFR kunye ne-EGFR mutants kunye ne-DC50 ye-11.7 nM kunye ne-22.3 nM ye-HCC827 iseli (Exon 19 del) kunye ne-H3258R cell (L8255R).

Ithagethi: EGFR