EAI-045

Igama leMchiza:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

Ikhowudi yoncumo:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Ikhowudi ye-InChi:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

Isitshixo se-InChi:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Igama elingundoqo:

EAI-045, EAI045, EAI 045, 1942114-09-1

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-EAI045 ia inamandla kunye ne-EGFR inhbitor ekhethiweyo. I-EAI045 ijolise ekukhetheni iinguqu ze-EGFR ezinganyangekiyo ngamachiza kodwa igcina i-wild-type receptor. I-EAI045 inqanda i-L858R / T790M-mutant EGFR kunye ne-low-nanomolar potency kwiimvavanyo ze-biochemical.

Ithagethi: EGFR