iNazartinib; EGF816; I-NVS-816

Igama leMchiza:

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)kodwa-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)- I-2-methylisonicotinamide

Ikhowudi yoncumo:

O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4

Ikhowudi ye-InChi:

InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5, 8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1

Isitshixo se-InChi:

IOMMMLWIABWRKL-WUTDNEBXSA-N

Igama elingundoqo:

Nazartinib ,EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-Nazartinib, eyaziwa ngokuba yi-EGF816 kunye ne-NVS-816, ifumaneka ngomlomo, ayinakuguqulwa, isizukulwana sesithathu, i-mutant-selective epidermal growth factor receptor (EGFR) inhibitor, enokuthi isebenze i-antineoplastic. I-EGF816 ibophelela ngokudibeneyo kwaye inqanda umsebenzi weefom eziguqukayo ze-EGFR, kubandakanywa ne-T790M EGFR iguquguquko, ngaloo ndlela ikhusela ukubonakaliswa kwe-EGFR-mediated. Oku kunokubangela ukufa kweeseli kunye nokuthintela ukukhula kwethumba kwi-EGFR-overexpressing tumor cells. I-EGF816 ngokukhethekileyo inqanda iifom eziguquliweyo ze-EGFR kuquka i-T790M, inguquko efunyenwe okwesibini yokuxhathisa, kwaye ingaba neenzuzo zonyango kumathumba ane-T790M-mediated resistance xa kuthelekiswa nezinye i-EGFR tyrosine kinase inhibitors.

Ithagethi: EGFR