JBJ-04-125-02 R-isomer
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
Igama leMchiza:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl)i-acetamide
Ikhowudi yoncumo:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Ikhowudi ye-InChi:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28( 35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
Isitshixo se-InChi:
VHQVOTINPRYDAO-AREMUKBSSA-N
Igama elingundoqo:
Ukunyibilika:
Ugcino:
Inkcazo:
I-JBJ-04-125-02 i-mutant-selective EGFR allosteric inhibitor enomsebenzi onokuthi ube ne-anticancer. Njenge-arhente enye, inokuthintela ukwanda kweeseli kunye ne-EGFRL858R/T790M/C797S yokubonisa i-in vitro kunye ne-vivo. Ukudityaniswa kwe-osimertinib kunye ne-JBJ-04-125-02 kubangela ukwanda kwe-apoptosis, inhibition esebenzayo yokukhula kweselula, kunye nokusebenza okwandisiweyo kwi-vitro kunye ne-vivo xa kuthelekiswa ne-arhente enye yodwa.
Ithagethi: EGFR
