I-AZD-3409

Igama leMchiza:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

Ikhowudi yoncumo:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Ikhowudi ye-InChi:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36- 19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1- 3H3,(H,39,40)/t28-,29-,31-/m0/s1

Isitshixo se-InChi:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Igama elingundoqo:

I-AZD3409; I-AZD-3409; I-AZD 3409

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-AZD-3409 sisithinteli esinamandla se-prenyl transferase. I-AZD-3409 ibonise amandla aphezulu kunelonafarnib. I-IC (50) ye-cytotoxicity ye-AZD3409 yayiyi-510 kwiiseli ze-MEF, i-10,600 kwiiseli ze-A549 kunye ne-6,170 kwiiseli ze-MCF7, ngokulandelanayo. Kwezi seli, i-IC (50) yomsebenzi we-FTase we-AZD3409 ukusuka kwi-3.0 ukuya kwi-14.2 nM kunye ne-lonafarnib ukusuka kwi-0.26 ukuya kwi-31.3 nM. I-AZD3409 inqanda i-farnesylation ukuya kwinqanaba eliphezulu kune-gernylgeranylation. Zombini inhibition ye-farnesylation kunye ne-geranylgeranylation ayikwazanga ukunxibelelana nomsebenzi wokuchasana neyeza. I-AZD3409 inokuba iyasebenza kwi-gefitinib-resistant breast carcinoma.

Ithagethi: prenyl transferase inhibitor