Osimertinib Mesylate

Igama leMchiza:

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino )phenyl)acrylamide mesylate

Ikhowudi yoncumo:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

Ikhowudi ye-InChi:

InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28 )20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2 -6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

Isitshixo se-InChi:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Igama elingundoqo:

AZD-9291, AZD9291, AZD 9291, Tagrisso,Osimertinib Mesylate, 1421373-66-1

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-Osimertinib, eyaziwa ngokuba yi-mereletinib kunye ne-AZD-9291, isizukulwana sesithathu se-EGFR inhibitor, ibonise isithembiso kwizifundo ze-preclinical kwaye inika ithemba kwizigulane ezinomhlaza wemiphunga ophezulu oye waxhathisa kwi-EGFR inhibitors ekhoyo. I-AZD9291 iyasebenza kakhulu kwiimodeli zangaphambili kwaye inyamezeleka kakuhle kwiimodeli zezilwanyana. Ithintela zombini iinguqu ze-EGFR ezisebenzayo kunye nezixhathisayo ngelixa ugcina uhlobo oluqhelekileyo lwe-EGFR ekhoyo kwiiseli eziqhelekileyo zesikhumba kunye namathumbu, ngaloo ndlela inciphisa iziphumo ebezingalindelekanga ezifunyenwe kumayeza akhoyo ngoku. I-Osimertinib yamkelwa ngoNovemba ka-2015.

Ithagethi: EGFR