Poziotinib
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 1g | Ikhona evenkileni | 790 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-enye
Ikhowudi yoncumo:
C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
Ikhowudi ye-InChi:
InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27- 12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27 , 28, 29)
Isitshixo se-InChi:
LPFWVDIFUFFKJU-UHFFFAOYSA-N
Igama elingundoqo:
Poziotinib, HM-781-36, HM-781-36B, NOV-1201,NOV-120101, 1092364-38-9
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-Poziotinib i-inhibitor enamandla ye-EGFR family kinases ene-IC50 values ye-3.2, 5.3, 23.5, 4.2, kunye ne-2.2 nM ye-wild-type EGFR, HER2, HER4, EGFRT790M, kunye ne-EGFRL858R/T790M, ngokulandelanayo. Inobukhulu obungaphezu kwe-100 ukuya kwi-1,000-fold selectivity ye-EGFR kinases ngaphezu kwe-30 enye i-kinases evavanyiweyo kwi-vitro. I-Poziotinib inqanda ukukhula kohlobo lwasendle kunye ne-mutant EGFR kinase-dependent lung, ibele, kunye ne-gastric cancer cell lines (GI50s = 0.6-5.7 nM) kwaye inqanda i-EGFR phosphorylation kwaye ibangela i-apoptosis in vitro. Kwi-vivo, i-poziotinib yehlisa ubungakanani bethumba kwimodeli ye-xenograft ye-HCC827 engeyincinci yeseli yomhlaza wemiphunga. Imiqulu equlethe i-poziotinib iphantsi kophando kulingo lwezonyango lonyango lwe-EGFR-mutant lung adenocarcinoma.
Ithagethi: EGFR
