Bardoxolone

Bardoxolone
  • Igama:Bardoxolone
  • Inombolo yekhathalogu:CPD1017
  • Inombolo yeCAS:218600-44-3
  • Ubunzima beMolekyuli:491.672
  • Ifomula yemichiza:C31H41NO4
  • Kuphando lwenzululwazi kuphela, hayi izigulane.

    Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Ubungakanani bePakethi Ubukho Ixabiso (USD)
    100mg Ikhona evenkileni 300
    500mg Ikhona evenkileni 1000
    1g Ikhona evenkileni 1700
    Iisayizi ezininzi Fumana iiQuotes Fumana iiQuotes

    Igama leMchiza:

    (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-diox o-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic iasidi

    Ikhowudi yoncumo:

    CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@]2([C@]13[H ])[H])C)C(O)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)C4=CC3=O)=O

    Ikhowudi ye-InChi:

    InChI=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22- 28(5)15-18(17-32)24(34 )27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36) /t19-,21-,23-,28-,29+,30+,31-/m0/s1

    Isitshixo se-InChi:

    TXGZJQLMVSIZEI-UQMAOPSPSA-N

    Igama elingundoqo:

    Bardoxolone, RTA 402, CCDO, RTA-402, RTA402, 218600-44-3

    Ukunyibilika:Inyibilika kwi-DMSO

    Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).

    Inkcazo:

    Amacandelo ezintso ezivela kwi-Bardoxolone methyl-treated monkeys ibonisa ukunciphisa i-megalin protein expression nangona i-mRNA ibonakaliso efanayo kumaqela. Ukuncipha okubonakalayo kwinkcazo yeprotheyini ye-megalin iqinisekiswa ngokuhlalutya kwe-densitometry, ebonisa ukuba ulawulo lwe-Bardoxolone methyl lunciphisa kakhulu i-megalin protein expression kwi-monkey kidney. Ulawulo lwe-Bardoxolone methyl aluchaphazeli ukubonakaliswa kweprotheyini ye-cubilin kwizintso okanye ukubonakaliswa kwe-mRNA ye-cubilin kwizintso. Ukukhutshwa kwe-creatinine kwiinkawu ezilawulwa yi-Bardoxolone methyl yahluke kakhulu kwisiseko kunye nezilwanyana eziphathwa ngemoto ngosuku lwe-28. Emva kweentsuku ze-28 zolawulo lwe-Bardoxolone methyl, i-urinary albumin-to-creatinine ratios (UACRs), enqunywe ukusuka kumchamo weeyure ze-24. ingqokelela, yande kakhulu xa ithelekiswa nezo zezilwanyana ezifumana isithuthi. Inqaku, i-UACRs iyancipha i-53.3% kwizilwanyana eziphathwa ngemoto kwaye yanda i-27.9% kwi-monkeys ye-Bardoxolone methyl [3]. Iigundane ze-C57BL / 6J zamadoda zilawulwa ngomlomo we-BARD ngexesha lokutya kwe-HFD (HFD / BARD), kuphela ukutya okunamafutha aphezulu (HFD), okanye ukutya okunamafutha aphantsi (LFD) kwiiveki ze-21. Xa kuthelekiswa neempuku ze-LFD, iimpuku ze-HFD zinokunyuka okuphawulweyo kwinani le-F4/80 yezakhiwo ezifana nesithsaba (+95%; p<0.001), ethintelwa ngokufanelekileyo yi-BARD (-50%; p<0.01). Ngokufanayo, inani le-F4/80 interstitial macrophages liphezulu kakhulu kwiimpuku ze-HFD nge-98% (p<0.001) xa kuthelekiswa neempuku ze-LFD kunye ne-32% (iphe<0.01) xa kuthelekiswa neempuku ze-HFD/BARD[4].

    Ithagethi: Nrf-2




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