AZD7507
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | ikhona evenkileni | Fumana ikhowuti |
| 500mg | ikhona evenkileni | Fumana ikhowuti |
| 1g | ikhona evenkileni | Fumana ikhowuti |
Igama leMchiza:
4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
Ikhowudi yoncumo:
O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N
Ikhowudi ye-InChi:
InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31)20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2 ,25,32)(H,26,27)
Isitshixo se-InChi:
CPDGCAFPSYOTGO-UHFFFAOYSA-N
Igama elingundoqo:
I-AZD7507; I-AZD-7507; I-AZD 7507
Ukunyibilika:I-DMSO
Ugcino:
Inkcazo:
I-AZD7507 inamandla kwaye ikhetha i-CSF-1R inhibitor (i-32 nM cell activity), i-AZD7507 ithathwa njengekhompawundi ethembisayo njengoko igcina amandla afunekayo kunye neepropati zomlomo ze-pharmacokinetic ze-AZ683. Ngaphezu koko, kwisifundo se-telemetry kwizinja ezinikwe umthamo omnye womlomo, kwakungekho tyhefu ye-cardiovascular, akukho ukuphakama kwe-troponin enxulumene nonyango, kwaye akukho tshintsho kwi-ECG.
Ithagethi: CSF-1R
